The COVID-19 pandemic has resulted in more than 524 million cases and 6 million deaths worldwide. Various drug interventions targeting multiple stages of COVID-19 pathogenesis can significantly reduce infection-related mortality. The current within-host mathematical modeling study addresses the optimal drug regimen and efficacy of combination therapies in the treatment of COVID-19. The drugs/interventions considered include Arbidol, Remdesivir, Interferon and Lopinavir/ritonavir. It is concluded that these drugs, when administered singly or in combination, reduce the number of infected cells and viral load. (...) Four scenarios dealing with the administration of a single drug, two drugs, three drugs and all four are discussed. In all these scenarios, the optimal drug regimen is proposed based on two methods. In the first method, these medical interventions are modeled as control interventions and a corresponding objective function and optimal control problem are formulated. In this framework, the optimal drug regimen is derived. Later, using the comparative effectiveness method, the optimal drug regimen is derived based on the basic reproduction number and viral load. The average number of infected cells and viral load decreased the most when all four drugs were used together. On the other hand, the average number of susceptible cells decreased the most when Arbidol was administered alone. The basic reproduction number and viral load decreased the most when all four interventions were used together, confirming the previously obtained finding of the optimal control problem. The results of this study can help physicians make decisions about the treatment of the life-threatening COVID-19 infection. (shrink)

The nature of contemporary issues facing our society and the research being conducted to deal with them clearly crosses the boundaries of traditional academic disciplines. Hence, it is suggested that school education should provide students with trans-disciplinary learning experiences in which students learn to use knowledge from various academic disciplines in an integrated format within the context of specific real-life issues. Trans-disciplinary approaches hold the promise of helping students see real-life issues in an organic rather than fragmented manner and be (...) able to apply knowledge to deal with them in an organic manner. A majority of the contemporary issues facing our society relate to the environment. Hence, environmental issues can serve as excellent organizers for designing trans-disciplinary instructional units. Arguments in favor of organizing trans-disciplinary instruction around contemporary environmental issues and an approach for doing so are presented in this article. (shrink)

This book examines the interface between Buddhism and the caste system in India. It discusses how Buddhism in different stages, from its early period to contemporary forms-Theravāda, Mahāyāna, Tantrayāna and Navayāna-dealt with the question of caste. It also traces the intersections between the problem of caste with those of class and gender. The volume reflects on the interaction between Hinduism and Buddhism: it looks at critiques of caste in the classical Buddhist tradition while simultaneously drawing attention to the radical challenge (...) posed by Dr B. R. Ambedkar's Navayāna Buddhism or neo-Buddhism. The essays in the book further compare approaches to varṇa and caste developed by modern thinkers such as M. K. Gandhi and S. Radhakrishnan with Ambedkar's criticisms and his departures from mainstream appraisals. With its interdisciplinary methodology, combining insights from literature, philosophy, political science and sociology, the volume explores contemporary critiques of caste from the perspective of Buddhism and its historical context. By analyzing religion through the lens of caste and gender, it also forays into the complex relationship between religion and politics, while offering a rigorous study of the textual tradition of Buddhism in India. This book will be useful to scholars and researchers of Indian philosophy, Buddhist studies, Indology, literature, exclusion and discrimination studies, history, political studies, women studies, sociology, and South Asian studies. (shrink)

To what extent does the black hole information paradox lead to violations of quantum mechanics? I explain how black hole complementarity provides a framework to articulate how quantum characterizations of black holes can remain consistent despite the information paradox. I point out that there are two ways to cash out the notion of consistency in play here: an operational notion and a descriptive notion. These two ways of thinking about consistency lead to (at least) two principles of black hole complementarity: (...) an operational principle and a descriptive principle. Our background philosophy of science regarding realism/instrumentalism might initially lead us to prefer one principle over the other. However, the recent physics literature, which applies tools from quantum information theory and quantum computational complexity theory to various thought experiments involving quantum systems in or around black holes, implies that the operational principle is successful where the descriptive principle is not. This then lets us see that for operationalists the black hole information paradox might no longer be pressing. (shrink)

In this paper, we employ bibliometric analysis to empirically analyse the research on social entrepreneurship published between 1996 and 2017. By employing methods of citation analysis, document co-citation analysis, and social network analysis, we analyse 1296 papers containing 74,237 cited references and uncover the structure, or intellectual base, of research on social entrepreneurship. We identify nine distinct clusters of social entrepreneurship research that depict the intellectual structure of the field. The results provide an overall perspective of the social entrepreneurship field, (...) identifying its influential works and analysing scholarly communication between these works. The results further aid in clarifying the overall centrality features of the social entrepreneurship research network. We also examine the integration of ethics into social entrepreneurship literature. We conclude with a discussion on the structure and evolution of the social entrepreneurship field. (shrink)

Eine geradezu mythologische Narration des Okzidents besagt, dass der Mensch mit der europäischen Aufklärung begonnen habe, sein Schicksal nicht mehr übergeordneten Instanzen zu überlassen, sondern es im mutigen Vertrauen auf die eigenen Potenzen in die eigene Hand zu nehmen. Mal abgesehen davon, dass dieser Topos vom selbstbestimmten Menschen die Mythologien und Heldenepen zahlreicher, auch nichteuropäischer Kulturen prägt, scheint an der neuzeitlichen europäischen Narration doch zumindest auffällig, ihr Ideal von Selbstwerdung wie auch gesellschaftlicher und individueller Vervollkommnung an die Vorstellung stetigen Fortschritts (...) zu binden. Am Beispiel einiger zentraler hinduistischer Vorstellungen werde ich aus einer kulturpsychologischen Perspektive zu skizzieren versuchen, dass individuelle Perfektionierung auch in kosmologischen Vorstellungen als möglich gedacht werden kann, in denen stetige Auflösung und Zerstörung als Prinzip alles Seins betont werden. Abschließend werden einige knappe Überlegungen dazu angestellt, wie derartige Vorstellungen dazu beitragen können, bestimmte Aspekte gegenwärtiger Gesellschaft und Politik umfassender zu analysieren.Sri Krishna:Ich bin der Tod, der Zerstörer von Welten.[...] Ich bin die Zeit, die Verschwenderin von Völkern. Ich mache den Augenblick reif für ihren Zerfall.Arjuna:Feuergesichtiger, du hauchst die Welten zu Asche. [...] Die furchtbaren Hauer all deiner Münder knirschen. [...] In deinem grausamen Rachen liegen sie alle, auch die Krieger, ihre Häupter zertrümmert.(Verse aus der Bhagavadgita, Kap. 11). (shrink)

Journal of Human Values, Volume 28, Issue 3, Page 181-199, September 2022. The study addresses the challenging crisis of sustainable consumption. It explores the philosophy of Samkhya, which is based on nature and spirit, also found in Vedantic knowledge, and synthesizes it with the knowledge of spiritual well-being found in modern literature to conceptualize the roles of the direct, mediating and moderated mediation relationships of different Vedantic personality types, spiritual well-being and family structure with consciousness for sustainable consumption and its (...) three dimensions of environment, society and economy. Based on the conceptualized roles, different models have been proposed. (shrink)

The year 2018 is the 150 anniversary of the Tata group. This article is an attempt to examine the role of spiritual family values in shaping Tata as a sustainable business. Jamsetji Nusserwanji Tata, the founder of Tata, was a trained Parsi priest, who was greatly influenced by Humata or good thoughts, Hukhta or good words, and Hvarshta or good deeds toward others. Since its founding in 1868, the Tata leadership legacy has persistently followed those watchwords of the Zoroastrian faith. (...) The extant workplace spirituality literature posits that the role of spiritual and religious values is vital for organizations and individuals to prosper. Employing historical data and biographical method, we trace the history of Tata to examine the causal mechanism between spirituality and sustainable business, under the influence of stakeholder concept, sustainability and family values-based leadership. Implications for research and practice are discussed. (shrink)

Taking psychology and its attempt to deal scientifically with the meaning of culture as an example, this article outlines the meaning of various historiographic narratives of disciplinary self-perception with regard to tensions between the natural and cultural sciences. The thesis postulates that these self-images are of psychological, especially cultural-psychological, importance. Only a psychology that includes aspects of the cultural sciences is able to deal with this vital aspect of the broader field.

In this study, we employed a combination of bibliometric analysis and a structured review approach to examine the social entrepreneurship (SE) research. Our bibliometric analysis involved 2517 articles containing 155,846 references and we analyzed the data in three time periods: 1990–2009, 2010–2014, and 2015–2020 to detect longitudinal trends. This analysis helped us to identify the intellectual foundation of each period and the evolution of the intellectual structure of SE research. We specifically identified 13, 9, and 11 clusters that constituted the (...) philosophical foundations of SE research for the periods 1990–2009, 2010–2014, and 2015–2020 respectively. A longitudinal comparison of three periods helped us to trace the evolution of the intellectual structure of SE research. Further, the structured review, involving 106 recent influential articles, enabled us to identify 10 recent dominant themes of SE research. Building on our bibliometric and structured review approach, we developed an organizing framework for guiding future SE research across six dimensions: ethics, individual, community, collaborative, organizational, and contextual. (shrink)

Frequency selective surface -based intelligent spatial filters are capturing the eyes of the researchers by offering a dynamic behavior when exposed to the electromagnetic radiations. In this manuscript, a concept of creating complementary structures which stems from Babinet’s principle is illustrated. A hybrid complementary pair of FSS comprising double square loop FSS and double square slot FSS on either side of the dielectric substrate is proposed. DSLFSS offers band-pass behavior and can be placed as a superstrate, whereas DSSFSS behaves as (...) a band-stop intelligent spatial filter that blocks the radiations falling on it, thus making them applicable for use as a substrate. The technique utilized for analyzing DSLFSS and DSSFSS structures is based on the equivalent circuit modeling and transmission line methodology. The CPFSS structure offers the design simplicity, hence, suitable for placing them with the printed patch antenna radiators in wireless networking devices operating in sub-6 GHz 5G spectrum. DSLFSS offers band-pass behavior ranging from 2.99 to 5.56 GHz, whereas DSSFSS offers band-stop behavior ranging from 2.85 to 5.42 GHz covering all n77, n78, and n79 bands of FR1 spectrum of sub-6 GHz 5G range. The passband and the stopband offered by the two structures of CPFSS geometry are stable to oblique angles of incidence and the proposed design also offers polarization-independent behavior. The thickness of the dielectric region existing within the pair of designed structures is critical for the location of the passbands and the stopbands. The impact of the overall thickness of the dielectric substrate on the passbands and stopbands is also reported in this article. (shrink)

Following Lyotard's death in 1998, this book provides an exploration of the recurrent theme of education in his work. It brings to a wider audience the significance of a body of thought about education that is subtle, profound and still largely unexplored. This book also makes an important contribution to contemporary debates on postmodernism and education.

Structural realism is the view that scientific theories give us knowledge only of the structure of the unobservable world. The view faces an influential objection that was first posed by Max Newman: if our knowledge of the unobservable world were strictly limited to its structure, our knowledge turns out to be trivial, for it amounts to nothing more than knowledge of the cardinality of the world. In this paper, I shall propose a response to Newman’s objection. It shall be argued (...) that in having epistemic access to the intrinsic nature of our conscious experiences—knowledge that structural realists allow for—we have knowledge of what it is to exist as concrete phenomena. With the plausible assumption that the relations of the unobservable world are also similarly concrete, one can address Newman’s objection. I shall further contrast this response to other similar responses that have been proposed, and also address the objection that this response is not available to structural realists. (shrink)

The aim of this article was to discuss the modeling and control method of quadrotor unmanned aerial vehicle. In the process of modeling, mechanism modeling and experimental testing are combined, especially the motor and propeller are modeled in detail. Through the understanding of the body structure and flight principle of the quadrotor UAV, the Newton–Euler method is used to analyze the dynamics of the quadrotor UAV, and the mathematical model of the UAV is established under the small angle rotation. Process (...) identifier is used to control it. First, the attitude angle of the model is controlled by PID, and based on this, the speed in each direction is controlled by PID. Then, the PID control of the four rotor aircraft with the center of gravity offset is simulated by MATLAB. The results show that the pitch angle and roll angle can be controlled by 5 degrees together without center of gravity deviation, and the PID can effectively control the control quantity and achieve the desired effect in a short time. Classical BP algorithm, classical GA-BP algorithm, and improved GA-BP algorithm were trained, respectively, with a total of 150 sets of training data, training function uses Levenberg-Marquardt, and performance function uses mean squared error. In the background of the same noise, the improved GA-BP algorithm has the highest detection rate, classical GA-BP algorithm is the second, and classical BP algorithm is the worst. The simulation results show that the PID control law can effectively control the attitude angle and speed of the rotor UAV in the case of center of gravity deviation. (shrink)

The justification and rationality of this paper is to present some fundamental principles, theories, and concepts that we believe moulds the nucleus of a good artificial intelligence (AI) society. The morally accepted significance and utilitarian concerns that stems from the inception and realisation of an AI’s structural foundation are displayed in this study. This paper scrutinises the structural foundation, fundamentals, and cardinal righteous remonstrations, as well as the gaps in mechanisms towards novel prospects and perils in determining resilient fundamentals, accountability, (...) and AI’s convoluted and responsible implications. We outline a number of salient and practical benefits, in which to place moral norms within the mise en scène of AI, to delineate the rudimentary ethical dilemmas and decorous directions within the realms of AI. (shrink)

We define a new type of “shatter function” for set systems that satisfies a Sauer–Shelah type dichotomy, but whose polynomial-growth case is governed by Shelah’s two-rank instead of VC dimension. We identify the least exponent bounding the rate of growth of the shatter function, the quantity analogous to VC density, with Shelah’s $\omega $ -rank.

This book offers a systematic and radical introduction to the Buddhist roots of Pātañjalayoga or the Yoga system of Patañjali. By examining each of 195 aphorisms of the Yogasūtra, along with discussions on the Yogabhāṣya, it shows that traditional and popular views on Pātañjalayoga obscure its true nature. The book argues that Patañjali's Yoga contains elements rooted in both orthodox as well as heterodox philosophical traditions, including Sāṅkhya, Jaina and Buddhist thought. With a fresh translation and a detailed commentary on (...) the Yogasūtra, the author unearths how several terms, concepts, and doctrines of Patañjali's Yoga can be traced to Buddhism, particularly the Abhidharma Buddhism of Vasubandhu and the early Yogācāra of Asaṅga. The work presents the Yogasūtra of Patañjali as a synthesis of two perspectives: the metaphysical perspective of Sāṅkhya and the empirical-psychological perspective of Buddhism. Based on a holistic understanding of Yoga, the study explores key themes of the text, such as meditative absorption, means, supernormal powers, isolation, Buddhist conceptions of meditation, the interplay between Sāṅkhya and Buddhist approaches to suffering and emancipation. It further highlights several new findings and clarifications on textual interpretation and discrepancies. An important intervention in Indian and Buddhist philosophy, this book opens a new way of looking at the Yoga of Patañjali in the light of Buddhism beyond standard approaches, and will greatly interest scholars and researchers of Buddhist studies, Yoga studies, Indian philosophy, philosophy in general, literature, religion and comparative studies, Indian and South Asian Studies, and the history of ideas. (shrink)

A historical investigation of the exclusion of Africa and Asia from modern histories of philosophy.

Philosophy in Indian tradition as a purely secular and rational exercise can be located in the Lokayata/Carvaka school of Indian philosophy. Due to the lack of substantial literary sources, scholars did not try to explore Lokayata philosophically. The present work is the first attempt to explore the philosophical energies inherent in the scattered Carvaka literature through critical and analytical discussions firmly grounded in textual evidences.

This article starts with a case outlining ethical challenges encountered in participatory action research (PAR) on vaccine hesitancy in rural India during Covid-19. Community researchers were recruited by a not-for-profit organisation, with the aim of both discovering the reasons for vaccine hesitancy and encouraging take-up. This raised issues about the roles and responsibilities of local researchers in their own communities, where they might be blamed for adverse reactions to vaccination. They and their mentor struggled with balancing societal protection against individual (...) rights to make choices. These themes are explored in two commentaries discussing the difficulties in balancing ethics in public health (prioritising societal benefits), social research (protecting participants from harm and respecting their rights not to be involved) and participatory research practices (maximising democratic participation and decision-making). As discussed in the first commentary, often these cohere, but tensions can arise. The second commentary also raises the issue of epistemic justice, questioning the extent to which the villagers could have a say in the design, implementation and interpretation of the research, and the dangers of not hearing the voices and arguments of people who reject vaccination. The case and commentaries highlight the complexities of PAR and additional challenges in a public health context. (shrink)

Is it possible to look at schools as spaces for encounters? Could schools contribute to a deliberative mode of communication in a manner better suited to our own time and to areas where different cultures meet? Inspired primarily by classical (Dewey) and modern (Habermas) pragmatists, I turn to Seyla Benhabib, posing the question whether she supports the proposition that schools can be sites for deliberative communication. I argue that a school that engages in deliberative communication, with its stress on mutual (...) communication between different moral perspectives, gives universalism a procedurally oriented meaning, serving as an arena for encounters that represents a weak public sphere. An interactive universalism of this kind attaches importance to developing an ability and willingness to reason on the basis of the views of others and to change perspectives. In that respect, the institutional arrangements of schools are potential parts of the political dimension of cosmopolitanism, as well as its moral dimension, in terms of the obligations and responsibilities we develop through our institutions and in our actions as human beings towards one another. (shrink)

Education lies at the heart of the Universal Declaration of Human Rights (UDHR): ‘Education shall be directed to the full development of the human personality and to the strengthening of respect for human rights and fundamental freedoms’. However, when education is mentioned in the philosophical literature on human rights, or even within the literature on educational policy, it is usually within the context of its being treated as a specific right—as education as a human right rather than human rights education. (...) Taking rights and obligations to be intimately tied within a full human rights educational regime, I argue for the role of education in establishing and realizing freedom from poverty as a human right. The arguments for why this freedom should be considered a human right are compelling. I offer five educational moments in the human rights movement in general, and the arguments for freedom from poverty as a human right, more specifically, in my discussion of human rights education. (shrink)